Endocrine Abstracts

Introduction: Surgery is the primary therapy in most acromelagic patients. When persistent disease is observed, adjuvant medical therapy is used. Pasireotide is a somatostatin analogue (SSA) not approved for acromegaly therapy yet, but with a potentially better response, given that it binds to four out of five somatostatin receptors.Materials and methods: We present the case of an acromegalic patient with resistance to many therapies and response to trea...

Introduction and objectives: The strategies for therapy of metastatic medullary thyroid carcinoma (MTC) are limited. Although Tyrosine kinase inhibitors (TKI) seem to be the first-line treatment, we want to explore other possibilities. Metaiodobenzylguanidine (MIBG) is a guanethidine derivative, structurally similar to norepinephrine. It was developed as an imaging agent with 123I radiolabeling. MIBG localizes neuroendocrine tumors including MTC. We are investigatin...

Aim: To determine, in type 1 diabetes mellitus (T1DM) patients, if there is any relationship between the age at onset and the number of HLA risk alleles for T1DM (DRB1*03 and DRB1*04).Methods: Retrospective study. We selected patients with T1DM diagnosis (pancreatic autoimmunity and insulin-dependent diabetes) and age at onset >15 years, identifying 275 subjects (59.6% men and 40.4% women), with a median age at onset of 31 years (interquartile range ...